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Synthesis and trafficking of the tonoplast potassium channel AtTPK1
(1) Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Milan, Italy (2) Institut fur Biochemie und Biologie, Universitaet Potsdam, Potsdam-Golm, Germany
Sorting signals of tonoplast proteins and the pathway they follow through the endomembrane system are still poorly characterized. Using Brefeldin A (an inhibitor of the Golgi-mediated traffic) we showed that a Golgi-dependent pathway for tonoplast delivery may exist. Then we generated various chimeric TPK1-TPK4 fusions, exchanging various domains. We observed that the cytosolic, C-terminal domain of TPK1 is sufficient to re-direct the plasma membrane TPK4 to the tonoplast.
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Anti-inflammatory activity of Dalbergia sissoo Roxb. heart-wood
L. M. College of Pharmacy
The heart-wood of Dalbergia sissoo Roxb. is reported to be used in traditional medicinal practices, of which anti-inflammatory is one. The present work evaluates the effect of the heart-wood extract on the carrageenan induced rat paw edema. The drug was found to be active at lowest of 3 doses tried. the drug can be said to posses anti-inflamatory activity but needs further evaluation of discover the pathway of the same.
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Compound Management Technologist, St Jude Children's Research Hospital, Memphis, TN
St. Jude Children's Research Hospital, located in Memphis, Tennessee, is a premier center for research and treatment of potentially fatal childhood diseases, including cancer and certain blood, genetic, and immunodeficiency disorders. The hospital's mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. St. Jude is dedicated to providing unsurpassed patient care and to advancing the health of children through biomedical research.
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Postdoctoral Research Associate
Northeastern University The Center for Drug Discovery at Northeastern University is dedicated to designing and discovering novel medications, developing technologies, and training scientists in the multidisciplinary field of drug discovery. We are recruiting a Postdoctoral Research Associate with expertise in protein-based mass spectrometry and /or proteomics.
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Product Manager - Techne, Stone, Staffordshire
Bibby Scientific Bibby Scientific Ltd is one of the world’s leading manufacturers of Laboratory bench-top scientific equipment. For more information about the company, please visit their website (www.bibby-scientific.com).
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Assistant/Associate Professors
Chinese University of Hong Kong The newly established School of Biomedical Sciences, Stem Cell and Regeneration theme is actively looking for stem cell biologist over the next 2 years.
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Macromolecular X-ray Crystallgrapher
Xtal Biostructures Ph.D. Protein Crystallographer: We seek an experienced crystallographer with post-doctoral experience to participate in a number of our diverse structural biology activities.
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Marketing Communications Specialist Position in San Jose, CA
Thermo Fisher Scientific This position, based in San Jose, CA within the SID Division, will manage promotion of Thermo Scientific mass spectrometry products and services.
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ADMET Europe, Munich, Germany
08 April 2010 - 09 April 2010
Select Biosciences is pleased to announce its 3rd annual ADMET Europe conference. Topics to be covered will include cutting edge discoveries in microdosing such as advances in the use of Accelerator Mass Spectrometry (AMS) to deliver microdoses, as well as advances in setups of in-vivo, in-vitro and in-silico techniques.
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Pharma Outsourcing Congress, Munich, Germany
08 April 2010 - 09 April 2010
Due to its continuing success, we are pleased to announce our 2nd Annual PharmaOutsourcing conference. Included will be a host of topics designed to give you new ideas and approaches for your outsourcing needs, as well as looking at implementing and managing clinical trials in Europe and Asia.
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Advances in Synthetic Chemistry
08 April 2010 - 09 April 2010
The 3rd annual Advances in Synthetic Biology aims to cover the following topics: The Chemistry of Synthetic Biology; Protein, Metabolic & Therapeutic Engineering; Bioinformatics and Software Modelling in Synthetic Biology; Cell & Tissue Engineering and The Road Towards the Rational and Systemic Design of Novel Biological Systems.
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Cleaning Microreactors
Syrris Ltd
This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
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